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TitleA Bioluminescent Ca Indicator Based on a Topological Variant of GCaMP6s.
Publication TypeJournal Article
Year of Publication2018
AuthorsQian, Yong, Vladimir Rancic, Jiahui Wu, Klaus Ballanyi, and Robert E. Campbell
JournalChembiochem
Date Published2018 Jun 22
ISSN1439-7633
Abstract

Rearranging the topology of an optimized genetically encoded Ca indicator produces a variant that retains the favorable properties of the original but also has new termini in closer proximity to the chromophore. Fusion of a bright luciferase to the new N terminus results in a highly effective glow-in-the-dark Ca indicator.

DOI10.1002/cbic.201800255
Alternate JournalChembiochem
PubMed ID29934970