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TitleA Bioluminescent Ca2+ Indicator Based on a Topological Variant of GCaMP6s.
Publication TypeJournal Article
Year of Publication2018
AuthorsQian, Yong, Vladimir Rancic, Jiahui Wu, Klaus Ballanyi, and Robert E. Campbell
Date Published2018 Jun 22

Rearranging the topology of an optimized genetically encoded Ca indicator produces a variant that retains the favorable properties of the original but also has new termini in closer proximity to the chromophore. Fusion of a bright luciferase to the new N terminus results in a highly effective glow-in-the-dark Ca indicator.

Alternate JournalChembiochem
PubMed ID29934970