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at the interface of physics & neuroscience

2017 | Canadian Neurophotonics Platform Short Course / Satellite

A Short Course by the Canadian Neurophotonics Platform

Date: May 28, 2017, 9AM to 4:00PM, at the Hotel Bonaventure, Montreal

One of the greatest challenges of modern science is to decipher the functional connectome of nature’s most complex organ, the human brain. A key to success in this effort is to develop and exploit technologies that allow us to probe and manipulate brain microcircuits from the level of single synapses – and even nanoscale substructures within synapses – to entire circuits in the intact brain in behaving animals.  Light-based tools represent the enabling technology in this endeavour.

Organizer: Ed Ruthazer, McGill University



9:00 WELCOME: Yves De Koninck (CERVO Brain Research Center, Université Laval)

9:10 SESSION 1: New technical advances in Neurophotonics  – Chair: Ed Ruthazer

9:10  Daniel Côté (CERVO Brain Research Center, Université Laval)

Rapid high resolution volumetric imaging with lightsheet microscopy

9:40 Robert Campbell (University of Alberta)

Optogenetic tools for neurophotonics

10:10 Darcy Peterka (Zuckerman Mind Brain Behavior Institute, Columbia University)

3D optical control of neural activity

10:40 COFFEE BREAK | Lobby

11:00 SESSION 2: Imaging the awake-behaving brain – Chair : Jaideep Bains

11:00 Jonathan Britt (McGill University/Concordia University)

Synchronized fluctuations in multiple excitatory inputs to the nucleus accumbens underlies food seeking behavior

11:30 Chen Yan (The Hospital for Sick Children, University of Toronto)

Using mini-microscope to investigate fear memory deficit in a mouse model of Alzheimer’s Disease

12:00 Tim Murphy (University of British Columbia)

Technologies for imaging mesoscale functional connectivity in mouse brain


14:00 SESSION 3- Optical approaches for studying synapses – Chair: Kurt Haas

14:00 Paul De Koninck (CERVO Brain Research Center, Université Laval)

Optical imaging of Netrin secretion and spatial dynamics to support synaptic plasticity

14:30 COFFEE BREAK | Lobby

14:50 Katalin Toth (CERVO Brain Research Center, Université Laval)

Fast two-photon imaging of subcellular voltage dynamics with new genetically encoded indicators

15:20 Jean-Claude Béïque (University of Ottawa)

Calibration and use of an optical sensor to study transmission at single synapses

15:50 CLOSING REMARKS: Yves De Koninck

17:00 Opening of the 11th Annual Canadian Neuroscience Meeting


An all-day short course to articulate new methods and applications of light microscopic imaging and optogenetic manipulation of nervous system tissues. Optogenetics topics include: optogenetic probe development, optogenetic activation and inhibition, with emphasis on region selective expression, light, and probe delivery.  Imaging topics include: in vivo approaches (2-photon fast scanning, wide-field), super-resolution imaging, and methodologies for assessing the structure and function of large brain networks.  Data analysis topics include visualization of activity in large networks, and image processing strategies to improve light microscopic images.


Mario Methot ( for further information.

Sponsored by: The Canadian Neurophotonics Platform funded by Brain Canada and partners