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TitleChloride Regulation: A Dynamic Equilibrium Crucial for Synaptic Inhibition.
Publication TypeJournal Article
Year of Publication2016
AuthorsDoyon, Nicolas, Laurent Vinay, Steven A. Prescott, and Yves De Koninck
Date Published2016 Mar 16
KeywordsAnimals, Chlorides, Homeostasis, Humans, Models, Biological, Neural Inhibition, Nonlinear Dynamics, Synapses

Fast synaptic inhibition relies on tight regulation of intracellular Cl(-). Chloride dysregulation is implicated in several neurological and psychiatric disorders. Beyond mere disinhibition, the consequences of Cl(-) dysregulation are multifaceted and best understood in terms of a dynamical system involving complex interactions between multiple processes operating on many spatiotemporal scales. This dynamical perspective helps explain many unintuitive manifestations of Cl(-) dysregulation. Here we discuss how taking into account dynamical regulation of intracellular Cl(-) is important for understanding how synaptic inhibition fails, how to best detect that failure, why Cl(-) regulation is energetically so expensive, and the overall consequences for therapeutics.

Alternate JournalNeuron
PubMed ID26985723
Grant List / / Canadian Institutes of Health Research / Canada