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TitleCircuits in the rodent brainstem that control whisking in concert with other orofacial motor actions.
Publication TypeJournal Article
Year of Publication2018
AuthorsMcElvain, Lauren E., Beth Friedman, Harvey J. Karten, Karel Svoboda, Fan Wang, Martin Deschênes, and David Kleinfeld
JournalNeuroscience
Volume368
Pagination152-170
Date Published2018 Jan 01
ISSN1873-7544
KeywordsAnimals, Behavior, Animal, Brain Stem, Facial Nucleus, Motor Activity, Mouth, Neural Pathways, Rodentia, Sensation, Touch Perception, Vibrissae
Abstract

The world view of rodents is largely determined by sensation on two length scales. One is within the animal's peri-personal space; sensorimotor control on this scale involves active movements of the nose, tongue, head, and vibrissa, along with sniffing to determine olfactory clues. The second scale involves the detection of more distant space through vision and audition; these detection processes also impact repositioning of the head, eyes, and ears. Here we focus on orofacial motor actions, primarily vibrissa-based touch but including nose twitching, head bobbing, and licking, that control sensation at short, peri-personal distances. The orofacial nuclei for control of the motor plants, as well as primary and secondary sensory nuclei associated with these motor actions, lie within the hindbrain. The current data support three themes: First, the position of the sensors is determined by the summation of two drive signals, i.e., a fast rhythmic component and an evolving orienting component. Second, the rhythmic component is coordinated across all orofacial motor actions and is phase-locked to sniffing as the animal explores. Reverse engineering reveals that the preBötzinger inspiratory complex provides the reset to the relevant premotor oscillators. Third, direct feedback from somatosensory trigeminal nuclei can rapidly alter motion of the sensors. This feedback is disynaptic and can be tuned by high-level inputs. A holistic model for the coordination of orofacial motor actions into behaviors will encompass feedback pathways through the midbrain and forebrain, as well as hindbrain areas.

DOI10.1016/j.neuroscience.2017.08.034
Alternate JournalNeuroscience
PubMed ID28843993
PubMed Central IDPMC5849401
Grant ListR01 NS077986 / NS / NINDS NIH HHS / United States
R01 NS058668 / NS / NINDS NIH HHS / United States
R21 NS101441 / NS / NINDS NIH HHS / United States
R01 MH085499 / MH / NIMH NIH HHS / United States
U01 NS090595 / NS / NINDS NIH HHS / United States