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TitleDevelopmental Potential and Plasticity of Olfactory Epithelium Stem Cells Revealed by Heterotopic Grafting in the Adult Brain.
Publication TypeJournal Article
Year of Publication2020
AuthorsLi, Qian, Tiziano Siri, Cedric Bressan, Yves De Koninck, and Armen Saghatelyan
JournalStem Cell Reports
Date Published2020 04 14
KeywordsAging, Animals, Brain, Cell Differentiation, Cell Movement, Cell Proliferation, Electrophysiological Phenomena, Heterografts, Male, Mice, Inbred C57BL, Neural Stem Cells, Neuronal Plasticity, Neurons, Olfactory Mucosa

The neural stem cells (NSCs) residing in the olfactory epithelium (OE) regenerate damaged olfactory sensory neurons throughout adulthood. The accessibility and availability of these NSCs in living individuals, including humans, makes them a promising candidate for harvesting their potential for cell replacement therapies. However, this requires an in-depth understanding of their developmental potential after grafting. Here, we investigated the developmental potential and plasticity of mouse OE-derived NSCs after grafting into the adult subventricular zone (SVZ) neurogenic niche. Our results showed that OE-derived NSCs integrate and proliferate just like endogenous SVZ stem cells, migrate with similar dynamics as endogenous neuroblasts toward the olfactory bulb, and mature and acquire similar electrophysiological properties as endogenous adult-born bulbar interneurons. These results reveal the developmental potential and plasticity of OE-derived NSCs in vivo and show that they can respond to heterotopic neurogenic cues to adapt their phenotype and become functional neurons in ectopic brain regions.

Alternate JournalStem Cell Reports
PubMed ID32243847
PubMed Central IDPMC7160358
Grant List PJT-159733 / / CIHR / Canada