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TitleThe Eloquent Silent Synapse.
Publication TypeJournal Article
Year of Publication2018
AuthorsVincent-Lamarre, Philippe, Michael Lynn, and Jean-Claude Béïque
JournalTrends Neurosci
Date Published2018 Sep

The ability of central synapses to undergo long-term potentiation (LTP) still captures the imagination of scientists and has become one of the most fascinating and deeply studied questions in modern neuroscience. By the mid-1990s, however, the field was deeply ensnarled in trying to answer a passionately dichotomous question: is LTP expressed by a pre- or a postsynaptic mechanism? Experimental results that could only be seen by many as being incontrovertibly contradictory presented a perplexing conundrum. However, two papers published in 1995 fundamentally redefined critical assumptions and provided a cunningly simple and elegant solution to an otherwise inextricable impasse.

Alternate JournalTrends Neurosci.
PubMed ID30143180