|Title||The Eloquent Silent Synapse.|
|Publication Type||Journal Article|
|Year of Publication||2018|
|Authors||Vincent-Lamarre, Philippe, Michael Lynn, and Jean-Claude Béïque|
|Date Published||2018 Sep|
The ability of central synapses to undergo long-term potentiation (LTP) still captures the imagination of scientists and has become one of the most fascinating and deeply studied questions in modern neuroscience. By the mid-1990s, however, the field was deeply ensnarled in trying to answer a passionately dichotomous question: is LTP expressed by a pre- or a postsynaptic mechanism? Experimental results that could only be seen by many as being incontrovertibly contradictory presented a perplexing conundrum. However, two papers published in 1995 fundamentally redefined critical assumptions and provided a cunningly simple and elegant solution to an otherwise inextricable impasse.
|Alternate Journal||Trends Neurosci.|