Title | The Eloquent Silent Synapse. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Vincent-Lamarre, Philippe, Michael Lynn, and Jean-Claude Béïque |
Journal | Trends Neurosci |
Volume | 41 |
Issue | 9 |
Pagination | 557-559 |
Date Published | 2018 Sep |
ISSN | 1878-108X |
Abstract | The ability of central synapses to undergo long-term potentiation (LTP) still captures the imagination of scientists and has become one of the most fascinating and deeply studied questions in modern neuroscience. By the mid-1990s, however, the field was deeply ensnarled in trying to answer a passionately dichotomous question: is LTP expressed by a pre- or a postsynaptic mechanism? Experimental results that could only be seen by many as being incontrovertibly contradictory presented a perplexing conundrum. However, two papers published in 1995 fundamentally redefined critical assumptions and provided a cunningly simple and elegant solution to an otherwise inextricable impasse. |
DOI | 10.1016/j.tins.2018.07.002 |
Alternate Journal | Trends Neurosci. |
PubMed ID | 30143180 |