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TitleEmbedded synaptic feedback in the neuroendocrine stress axis.
Publication TypeJournal Article
Year of Publication2015
AuthorsCusulin, J I. Wamsteek, and Jaideep S. Bains
JournalJ Neuroendocrinol
Volume27
Issue6
Pagination481-6
Date Published2015 Jun
ISSN1365-2826
Abstract

Neural regulation of blood glucocorticoid levels is critical for defence of homeostasis during physiological or psychoemotional challenges. In mammals, this function is carried out by the neuroendocrine stress axis, coordinated by parvocellular neuroendocrine cells (PNCs) of the paraventricular hypothalamic nucleus. Feedback regulation of PNCs by glucocorticoids provides complex experience-dependent shaping of neuroendocrine responses. We review recent evidence for metaplastic actions of glucocorticoids as 'circuit breakers' at synapses directly regulating PNC excitability and explore how such mechanisms may serve as substrates for stress adaptation.

DOI10.1111/jne.12260
Alternate JournalJ. Neuroendocrinol.
PubMed ID25612538