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TitleExperience salience gates endocannabinoid signaling at hypothalamic synapses.
Publication TypeJournal Article
Year of Publication2014
AuthorsCusulin, Jaclyn I. Wamsteek, Laura Senst, Campbell G Teskey, and Jaideep S. Bains
JournalJ Neurosci
Volume34
Issue18
Pagination6177-81
Date Published2014 Apr 30
ISSN1529-2401
KeywordsAnalgesics, Animals, Animals, Newborn, Benzoxazines, Disease Models, Animal, Dose-Response Relationship, Drug, Electroshock, Endocannabinoids, Hypothalamus, In Vitro Techniques, Inhibitory Postsynaptic Potentials, Male, Morpholines, Naphthalenes, Odors, Piperidines, Potassium Chloride, Pyrazoles, Rats, Rats, Sprague-Dawley, Signal Transduction, Stress, Psychological, Swimming, Synapses
Abstract

Alterations in synaptic endocannabinoid signaling are a widespread neurobiological consequence of many in vivo experiences, including stress. Here, we report that stressor salience is critical for bidirectionally modifying presynaptic CB-1 receptor (CB1R) function at hypothalamic GABA synapses controlling the neuroendocrine stress axis in male rats. While repetitive, predictable stressor exposure impairs presynaptic CB1R function, these changes are rapidly reversed upon exposure to a high salience experience such as novel stress or by manipulations that enhance neural activity levels in vivo or in vitro. Together these data demonstrate that experience salience, through alterations in afferent synaptic activity, induces rapid changes in endocannabinoid signaling.

DOI10.1523/JNEUROSCI.0163-14.2014
Alternate JournalJ. Neurosci.
PubMed ID24790188
Grant List / / Canadian Institutes of Health Research / Canada