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TitleFormula for Unsilencing Plasticity: Spike with GABA.
Publication TypeJournal Article
Year of Publication2015
AuthorsKesner, Philip, Delphine Gobert, and Edward S. Ruthazer
JournalNeuron
Volume87
Issue5
Pagination915-7
Date Published2015 Sep 2
ISSN1097-4199
KeywordsAction Potentials, Animals, Neuronal Plasticity, Neurons, Superior Colliculi, Vision, Ocular
Abstract

A complication for developmental plasticity mechanisms like spike-timing-dependent plasticity (STDP) is that immature postsynaptic neurons may lack sufficient input to fire action potentials. In this issue, van Rheede et al. (2015) report an activity-dependent mechanism that converts non-spiking cells into spiking neurons, priming them for further plasticity.

DOI10.1016/j.neuron.2015.08.016
Alternate JournalNeuron
PubMed ID26335639