| Title | Galectin-3: mediator of microglia responses in injured brain. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Rahimian, Reza, Louis-Charles Béland, and Jasna Kriz |
| Journal | Drug Discov Today |
| Volume | 23 |
| Issue | 2 |
| Pagination | 375-381 |
| Date Published | 2018 02 |
| ISSN | 1878-5832 |
| Abstract | Galectin-3 is a pleiotropic protein involved in cell activation, proliferation and migration and plays a pivotal part as an inflammatory mediator in neurodegeneration. Galectin-3 is associated with microglial activation and proliferation after ischemia. Given its putative role as a dynamic fine-tuner of microglia, activation of Galectin-3 provides molecular cues in design of new immunomodulatory strategies for stroke management. This review summarizes recent evidence on the role of Galectin-3 as a mediator of immune responses in damaged brain and mechanisms employed by Galectin-3 to affect microglial function. |
| DOI | 10.1016/j.drudis.2017.11.004 |
| Alternate Journal | Drug Discov. Today |
| PubMed ID | 29133191 |