|Title||Reconsolidation and the regulation of plasticity: moving beyond memory.|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Bonin, Robert P., and Yves De Koninck|
|Date Published||2015 Jun|
Memory reconsolidation is a protein synthesis-dependent process that preserves, in some form, memories that have been destabilized through recall. Reconsolidation is a nearly universal phenomenon, occurring in a diverse array of species and learning tasks. The function of reconsolidation remains unclear but it has been proposed as a mechanism for updating or strengthening memories. Observations of an analog of reconsolidation in vitro and in sensory systems indicate that reconsolidation is unlikely to be a learning-specific phenomenon and may serve a broader function. We propose that reconsolidation arises from the activity-dependent induction of two coincident but opposing processes: the depotentiation and repotentiation of strengthened synapses. These processes suggest that reconsolidation reflects a fundamental mechanism that regulates and preserves synaptic strength.
|Alternate Journal||Trends Neurosci.|
|Grant List||MOP 12942 / / Canadian Institutes of Health Research / Canada|