Search form

TitleReconsolidation and the regulation of plasticity: moving beyond memory.
Publication TypeJournal Article
Year of Publication2015
AuthorsBonin, Robert P., and Yves De Koninck
JournalTrends Neurosci
Volume38
Issue6
Pagination336-44
Date Published2015 Jun
ISSN1878-108X
Abstract

Memory reconsolidation is a protein synthesis-dependent process that preserves, in some form, memories that have been destabilized through recall. Reconsolidation is a nearly universal phenomenon, occurring in a diverse array of species and learning tasks. The function of reconsolidation remains unclear but it has been proposed as a mechanism for updating or strengthening memories. Observations of an analog of reconsolidation in vitro and in sensory systems indicate that reconsolidation is unlikely to be a learning-specific phenomenon and may serve a broader function. We propose that reconsolidation arises from the activity-dependent induction of two coincident but opposing processes: the depotentiation and repotentiation of strengthened synapses. These processes suggest that reconsolidation reflects a fundamental mechanism that regulates and preserves synaptic strength.

DOI10.1016/j.tins.2015.04.007
Alternate JournalTrends Neurosci.
PubMed ID25987442
Grant ListMOP 12942 / / Canadian Institutes of Health Research / Canada