Search form

TitleSynthesis of 3-chloro-6-((4-(di-tert-butyl[(18)F]fluorosilyl)-benzyl)oxy)-1,2,4,5-tetrazine ([(18)F]SiFA-OTz) for rapid tetrazine-based (18)F-radiolabeling.
Publication TypeJournal Article
Year of Publication2015
AuthorsZhu, Jun, Stephen Li, Carmen Wängler, Björn Wängler, Bruce R Lennox, and Ralf Schirrmacher
JournalChem Commun (Camb)
Volume51
Issue62
Pagination12415-8
Date Published2015 Aug 11
ISSN1364-548X
Abstract

An efficient method to prepare the (18)F-labeled tetrazine-derivative [(18)F]-SiFA-OTz for bioorthogonal radiochemistry was developed. [(18)F]-SiFA-OTz can be synthesized with a radiochemical yield of 78 ± 5% within 25 min and can quantitatively react with a model strained dienophile, trans-cyclooctenol.

DOI10.1039/c5cc03623b
Alternate JournalChem. Commun. (Camb.)
PubMed ID26145162