Search form

TitleA Wireless Optogenetic Headstage with Multichannel Electrophysiological Recording Capability.
Publication TypeJournal Article
Year of Publication2015
AuthorsGagnon-Turcotte, Gabriel, Alireza Avakh Kisomi, Reza Ameli, Charles-Olivier Dufresne Camaro, Yoan LeChasseur, Jean-Luc Néron, Paul Brule Bareil, Paul Fortier, Cyril Bories, Yves De Koninck, and Benoit Gosselin
JournalSensors (Basel)
Volume15
Issue9
Pagination22776-97
Date Published2015
ISSN1424-8220
Abstract

We present a small and lightweight fully wireless optogenetic headstage capable of optical neural stimulation and electrophysiological recording. The headstage is suitable for conducting experiments with small transgenic rodents, and features two implantable fiber-coupled light-emitting diode (LED) and two electrophysiological recording channels. This system is powered by a small lithium-ion battery and is entirely built using low-cost commercial off-the-shelf components for better flexibility, reduced development time and lower cost. Light stimulation uses customizable stimulation patterns of varying frequency and duty cycle. The optical power that is sourced from the LED is delivered to target light-sensitive neurons using implantable optical fibers, which provide a measured optical power density of 70 mW/mm² at the tip. The headstage is using a novel foldable rigid-flex printed circuit board design, which results into a lightweight and compact device. Recording experiments performed in the cerebral cortex of transgenic ChR2 mice under anesthetized conditions show that the proposed headstage can trigger neuronal activity using optical stimulation, while recording microvolt amplitude electrophysiological signals.

DOI10.3390/s150922776
Alternate JournalSensors (Basel)
PubMed ID26371006
PubMed Central IDPMC4610520