|Title||Galectin-3: mediator of microglia responses in injured brain.|
|Publication Type||Journal Article|
|Year of Publication||2018|
|Authors||Rahimian, Reza, Louis-Charles Béland, and Jasna Kriz|
|Journal||Drug Discov Today|
|Date Published||2018 02|
Galectin-3 is a pleiotropic protein involved in cell activation, proliferation and migration and plays a pivotal part as an inflammatory mediator in neurodegeneration. Galectin-3 is associated with microglial activation and proliferation after ischemia. Given its putative role as a dynamic fine-tuner of microglia, activation of Galectin-3 provides molecular cues in design of new immunomodulatory strategies for stroke management. This review summarizes recent evidence on the role of Galectin-3 as a mediator of immune responses in damaged brain and mechanisms employed by Galectin-3 to affect microglial function.
|Alternate Journal||Drug Discov. Today|