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TitleGalectin-3: mediator of microglia responses in injured brain.
Publication TypeJournal Article
Year of Publication2018
AuthorsRahimian, Reza, Louis-Charles Béland, and Jasna Kriz
JournalDrug Discov Today
Volume23
Issue2
Pagination375-381
Date Published2018 02
ISSN1878-5832
Abstract

Galectin-3 is a pleiotropic protein involved in cell activation, proliferation and migration and plays a pivotal part as an inflammatory mediator in neurodegeneration. Galectin-3 is associated with microglial activation and proliferation after ischemia. Given its putative role as a dynamic fine-tuner of microglia, activation of Galectin-3 provides molecular cues in design of new immunomodulatory strategies for stroke management. This review summarizes recent evidence on the role of Galectin-3 as a mediator of immune responses in damaged brain and mechanisms employed by Galectin-3 to affect microglial function.

DOI10.1016/j.drudis.2017.11.004
Alternate JournalDrug Discov. Today
PubMed ID29133191