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TitleMaternal immune activation in neurodevelopmental disorders.
Publication TypeJournal Article
Year of Publication2018
AuthorsSolek, Cynthia M., Na Farooqi, sr, Myriam Verly, Tony K. Lim, and Edward S. Ruthazer
JournalDev Dyn
Volume247
Issue4
Pagination588-619
Date Published2018 Apr
ISSN1097-0177
Abstract

Converging lines of evidence from basic science and clinical studies suggest a relationship between maternal immune activation (MIA) and neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia. The mechanisms through which MIA increases the risk of neurodevelopmental disorders have become a subject of intensive research. This review aims to describe how dysregulation of microglial function and immune mechanisms may link MIA and neurodevelopmental pathologies. We also summarize the current evidence in animal models of MIA. Developmental Dynamics 247:588-619, 2018. © 2017 Wiley Periodicals, Inc.

DOI10.1002/dvdy.24612
Alternate JournalDev. Dyn.
PubMed ID29226543