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TitleA novel wireless brain stimulation device for long-term use in freely moving mice.
Publication TypeJournal Article
Year of Publication2019
AuthorsAlpaugh, Melanie, Martine Saint-Pierre, Marilyn Dubois, Benoit Aubé, Dany Arsenault, Jasna Kriz, Antonio Cicchetti, and Francesca Cicchetti
JournalSci Rep
Volume9
Issue1
Pagination6444
Date Published2019 Apr 23
ISSN2045-2322
Abstract

Deep brain stimulation (DBS) has been used in clinical settings for many years despite a paucity of knowledge related to the anatomical and functional substrates that lead to benefits and/or side-effects in various disease contexts. In order to maximize the potential of this approach in humans, a better understanding of its mechanisms of action is absolutely necessary. However, the existing micro-stimulators available for pre-clinical models, are limited by the lack of relevant small size devices. This absence prevents sustained chronic stimulation and real time monitoring of animals during stimulation, parameters that are critical for comparison to clinical findings. We therefore sought to develop and refine a novel small wireless micro-stimulator as a means by which to study consequent behavioural to molecular changes in experimental animals. Building on previous work from our group, we refined our implantable micro-stimulator prototype, to be easily combined with intravital 2-photon imaging. Using our prototype we were able to replicate the well described clinical benefits on motor impairment in a mouse model of Parkinson's disease in addition to capturing microglia dynamics live during stimulation. We believe this new device represents a useful tool for performing pre-clinical studies as well as dissecting brain circuitry and function.

DOI10.1038/s41598-019-42910-7
Alternate JournalSci Rep
PubMed ID31015544
PubMed Central IDPMC6478908
Grant ListMOP-115190/243811 / / Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) /