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TitleParallel Inhibitory and Excitatory Trigemino-Facial Feedback Circuitry for Reflexive Vibrissa Movement.
Publication TypeJournal Article
Year of Publication2017
AuthorsBellavance, Marie-Andrée, Jun Takatoh, Jinghao Lu, Maxime Demers, David Kleinfeld, Fan Wang, and Martin Deschênes
JournalNeuron
Volume95
Issue3
Pagination673-682.e4
Date Published2017 Aug 02
ISSN1097-4199
KeywordsAnimals, Behavior, Animal, Brain Stem, Feedback, Female, Male, Mice, Motor Neurons, Movement, Rats, Long-Evans, Thalamus, Touch, Vibrissae
Abstract

Animals employ active touch to optimize the acuity of their tactile sensors. Prior experimental results and models lead to the hypothesis that sensory inputs are used in a recurrent manner to tune the position of the sensors. A combination of electrophysiology, intersectional genetic viral labeling and manipulation, and classical tracing allowed us to identify second-order sensorimotor loops that control vibrissa movements by rodents. Facial motoneurons that drive intrinsic muscles to protract the vibrissae receive a short latency inhibitory input, followed by synaptic excitation, from neurons located in the oralis division of the trigeminal sensory complex. In contrast, motoneurons that retract the mystacial pad and indirectly retract the vibrissae receive only excitatory input from interpolaris cells that further project to the thalamus. Silencing this feedback alters retraction. The observed pull-push circuit at the lowest-level sensorimotor loop provides a mechanism for the rapid modulation of vibrissa touch during exploration of peri-personal space.

DOI10.1016/j.neuron.2017.06.045
Alternate JournalNeuron
PubMed ID28735746
PubMed Central IDPMC5845798
Grant ListR01 NS077986 / NS / NINDS NIH HHS / United States
R01 NS058668 / NS / NINDS NIH HHS / United States
R21 NS101441 / NS / NINDS NIH HHS / United States
R01 MH085499 / MH / NIMH NIH HHS / United States
U01 NS090595 / NS / NINDS NIH HHS / United States