Search form

TitleParaventricular nucleus CRH neurons encode stress controllability and regulate defensive behavior selection.
Publication TypeJournal Article
Year of Publication2020
AuthorsDaviu, Nuria, Tamás Füzesi, David G. Rosenegger, Neilen P. Rasiah, Toni-Lee Sterley, Govind Peringod, and Jaideep S. Bains
JournalNat Neurosci
Volume23
Issue3
Pagination398-410
Date Published2020 03
ISSN1546-1726
KeywordsAccelerometry, Animals, Anticipation, Psychological, Corticotropin-Releasing Hormone, Cues, Electrophysiological Phenomena, Escape Reaction, Hindlimb Suspension, Male, Mice, Mice, Inbred C57BL, Neurons, Optogenetics, Paraventricular Hypothalamic Nucleus, Photic Stimulation, Stress, Psychological
Abstract

In humans and rodents, the perception of control during stressful events has lasting behavioral consequences. These consequences are apparent even in situations that are distinct from the stress context, but how the brain links prior stressful experience to subsequent behaviors remains poorly understood. By assessing innate defensive behavior in a looming-shadow task, we show that the initiation of an escape response is preceded by an increase in the activity of corticotropin-releasing hormone (CRH) neurons in the paraventricular nucleus (PVN) of the hypothalamus (CRH neurons). This anticipatory increase is sensitive to stressful stimuli that have high or low levels of outcome control. Specifically, experimental stress with high outcome control increases CRH neuron anticipatory activity, which increases escape behavior in an unrelated context. By contrast, stress with no outcome control prevents the emergence of this anticipatory activity and decreases subsequent escape behavior. These observations indicate that CRH neurons encode stress controllability and contribute to shifts between active and passive innate defensive strategies.

DOI10.1038/s41593-020-0591-0
Alternate JournalNat Neurosci
PubMed ID32066984
Grant ListFDN-148440 / / CIHR / Canada