Search form

TitleThe Quebec Parkinson Network: A Researcher-Patient Matching Platform and Multimodal Biorepository.
Publication TypeJournal Article
Year of Publication2020
AuthorsGan-Or, Ziv, Trisha Rao, Etienne Leveille, Clotilde Degroot, Sylvain Chouinard, Francesca Cicchetti, Alain Dagher, Samir Das, Alex Desautels, Janelle Drouin-Ouellet, Thomas Durcan, Jean-François Gagnon, Angela Genge, Jason Karamchandani, Anne-Louise Lafontaine, Sonia Lai Wing Sun, Mélanie Langlois, Martin Lévesque, Calvin Melmed, Michel Panisset, Martin Parent, Jean-Baptiste Poline, Ronald B. Postuma, Emmanuelle Pourcher, Guy A. Rouleau, Madeleine Sharp, Oury Monchi, Nicolas Dupré, and Edward A. Fon
JournalJ Parkinsons Dis
Volume10
Issue1
Pagination301-313
Date Published2020
ISSN1877-718X
Abstract

BACKGROUND: Genetic, biologic and clinical data suggest that Parkinson's disease (PD) is an umbrella for multiple disorders with clinical and pathological overlap, yet with different underlying mechanisms. To better understand these and to move towards neuroprotective treatment, we have established the Quebec Parkinson Network (QPN), an open-access patient registry, and data and bio-samples repository.

OBJECTIVE: To present the QPN and to perform preliminary analysis of the QPN data.

METHODS: A total of 1,070 consecutively recruited PD patients were included in the analysis. Demographic and clinical data were analyzed, including comparisons between males and females, PD patients with and without RBD, and stratified analyses comparing early and late-onset PD and different age groups.

RESULTS: QPN patients exhibit a male:female ratio of 1.8:1, an average age-at-onset of 58.6 years, an age-at-diagnosis of 60.4 years, and average disease duration of 8.9 years. REM-sleep behavior disorder (RBD) was more common among men, and RBD was associated with other motor and non-motor symptoms including dyskinesia, fluctuations, postural hypotension and hallucinations. Older patients had significantly higher rates of constipation and cognitive impairment, and longer disease duration was associated with higher rates of dyskinesia, fluctuations, freezing of gait, falls, hallucinations and cognitive impairment. Since QPN's creation, over 60 studies and 30 publications have included patients and data from the QPN.

CONCLUSIONS: The QPN cohort displays typical PD demographics and clinical features. These data are open-access upon application (http://rpq-qpn.ca/en/), and will soon include genetic, imaging and bio-samples. We encourage clinicians and researchers to perform studies using these resources.

DOI10.3233/JPD-191775
Alternate JournalJ Parkinsons Dis
PubMed ID31868683
PubMed Central IDPMC7029361
Grant ListP41 EB019936 / EB / NIBIB NIH HHS / United States
R01 MH083320 / MH / NIMH NIH HHS / United States
U24 DA039832 / DA / NIDA NIH HHS / United States
FDN-154301 / / CIHR / Canada