Title | Reconsolidation and the regulation of plasticity: moving beyond memory. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Bonin, Robert P., and Yves De Koninck |
Journal | Trends Neurosci |
Volume | 38 |
Issue | 6 |
Pagination | 336-44 |
Date Published | 2015 Jun |
ISSN | 1878-108X |
Abstract | Memory reconsolidation is a protein synthesis-dependent process that preserves, in some form, memories that have been destabilized through recall. Reconsolidation is a nearly universal phenomenon, occurring in a diverse array of species and learning tasks. The function of reconsolidation remains unclear but it has been proposed as a mechanism for updating or strengthening memories. Observations of an analog of reconsolidation in vitro and in sensory systems indicate that reconsolidation is unlikely to be a learning-specific phenomenon and may serve a broader function. We propose that reconsolidation arises from the activity-dependent induction of two coincident but opposing processes: the depotentiation and repotentiation of strengthened synapses. These processes suggest that reconsolidation reflects a fundamental mechanism that regulates and preserves synaptic strength. |
DOI | 10.1016/j.tins.2015.04.007 |
Alternate Journal | Trends Neurosci. |
PubMed ID | 25987442 |
Grant List | MOP 12942 / / Canadian Institutes of Health Research / Canada |