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TitleResistance of optogenetically evoked motor function to global ischemia and reperfusion in mouse in vivo.
Publication TypeJournal Article
Year of Publication2013
AuthorsXie, Yicheng, Shangbin Chen, Eitan Anenberg, and Timothy H. Murphy
JournalJ Cereb Blood Flow Metab
Date Published2013 Aug
KeywordsAnimals, Brain Ischemia, Brain Mapping, Electroencephalography, Electromyography, Lasers, Male, Mice, Mice, Transgenic, Neuroimaging, Physical Stimulation, Reperfusion Injury, Rhodopsin

Recently we have shown that despite reperfusion, sensory processing exhibits persistent deficits after global ischemia in a mouse in vivo model. We now address how motor output, specifically cortically evoked muscle activity, stimulated by channelrhodopsin-2 is affected by global ischemia and reperfusion. We find that the light-based optogenetic motor map recovers to 80% within an hour. Moreover, motor output recovers relatively faster and more completely than the sensory processing after 5-minute period of global ischemia. Our results suggest a differential sensitivity of sensory and motor systems to the effects of global ischemia and reperfusion that may have implications for rehabilitation.

Alternate JournalJ. Cereb. Blood Flow Metab.
PubMed ID23736644
PubMed Central IDPMC3734785
Grant ListMOP-111009 / / Canadian Institutes of Health Research / Canada