Robert E Campbell, Ph.D.

rc4@ualberta.ca
Campbell Lab | U Alberta
@Campbell_FPs

Office:

(780) 492-1849

Fax:

(780) 492-8231

Address:

Robert E. Campbell, Ph.D.
Professor
Department of Chemistry,
11227 Saskatchewan Drive,
University of Alberta,
Edmonton, Alberta
T6G 2G2 Canada

Google Scholar profile
orcid.org/0000-0003-0604-092X

Uses protein engineering to invent novel tools for neurophotonics

Scientific Advisor | Optogenetics Protein Engineering Facility
University of Alberta Centre of Excellence Leader

Professor - Department of Chemistry - University of Alberta

Robert E Campbell uses protein engineering to invent new tools for imaging dynamic biochemical events in live cells and tissues.

He distributes these tools to cell biologists and neuroscientists who apply them to address questions ranging from fundamental mechanisms in cell biology, to the underlying causes of mental illness, to the development of novel therapeutics.

A full list of projects and representative publications are available on his website: Campbell Group - Projects

Some of the proteins developed by Robert Campbell and his team at the Optogenetic protein engineering facility can be found in these databases:

FBbase.org

Fluorescent Biosensor Database at UCSD

Shen, Yi, Sheng-Yi Wu, Vladimir Rancic, Abhi Aggarwal, Yong Qian, Shin-Ichiro Miyashita, Klaus Ballanyi, Robert E. Campbell, and Min Dong. "Genetically encoded fluorescent indicators for imaging intracellular potassium ion concentration." Commun Biol 2 (2019): 18.
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Qian, Yong, Kiryl D. Piatkevich, Benedict Mc Larney, Ahmed S. Abdelfattah, Sohum Mehta, Mitchell H. Murdock, Sven Gottschalk, Rosana S. Molina, Wei Zhang, Yingche Chen et al. "A genetically encoded near-infrared fluorescent calcium ion indicator." Nat Methods 16, no. 2 (2019): 171-174.
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Wannier, Timothy M., Sarah K. Gillespie, Nicholas Hutchins, Scott R McIsaac, Sheng-Yi Wu, Yi Shen, Robert E. Campbell, Kevin S. Brown, and Stephen L. Mayo. "Monomerization of far-red fluorescent proteins." Proc Natl Acad Sci U S A 115, no. 48 (2018): E11294-E11301.
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Wiens, Matthew D., Yi Shen, Xi Li, Alaraby M Salem, Nick Smisdom, Wei Zhang, Alex Brown, and Robert E. Campbell. "Corrigendum: A Tandem Green-Red Heterodimeric Fluorescent Protein with High FRET Efficiency." Chembiochem 19, no. 6 (2018): 647.
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Wiens, M D., F Hoffmann, Y Chen, and R E. Campbell. "Enhancing fluorescent protein photostability through robot-assisted photobleaching." Integr Biol (Camb) 10, no. 7 (2018): 419-428.
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Qian, Yong, Vladimir Rancic, Jiahui Wu, Klaus Ballanyi, and Robert E. Campbell. "A Bioluminescent Ca Indicator Based on a Topological Variant of GCaMP6s." Chembiochem (2018).
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Zhao, Yufeng, Daniel Bushey, Yongxin Zhao, Eric R. Schreiter, Jed D Harrison, Allan M. Wong, and Robert E. Campbell. "Inverse-response Ca indicators for optogenetic visualization of neuronal inhibition." Sci Rep 8, no. 1 (2018): 11758.
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Chee, Ryan K. W., Yan Li, Wei Zhang, Robert E. Campbell, and Roger J. Zemp. "In vivo photoacoustic difference-spectra imaging of bacteria using photoswitchable chromoproteins." J Biomed Opt 23, no. 10 (2018): 1-11.
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Wu, Jiahui, Ahmed S. Abdelfattah, Hang Zhou, Araya Ruangkittisakul, Yong Qian, Klaus Ballanyi, and Robert E. Campbell. "Genetically Encoded Glutamate Indicators with Altered Color and Topology." ACS Chem Biol 13, no. 7 (2018): 1832-1837.
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Wiens, Matthew D., and Robert E. Campbell. "Surveying the landscape of optogenetic methods for detection of protein-protein interactions." Wiley Interdiscip Rev Syst Biol Med 10, no. 3 (2018): e1415.
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