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TitleShared Transcriptional Signatures in Major Depressive Disorder and Mouse Chronic Stress Models.
Publication TypeJournal Article
Year of Publication2020
AuthorsScarpa, Joseph R., Mena Fatma, Yong-Hwee E. Loh, Said Romaric Traore, Theo Stefan, Ting Huei Chen, Eric J. Nestler, and Benoit Labonté
JournalBiol Psychiatry
Date Published2020 Jul 15

BACKGROUND: Most of our knowledge of the biological basis of major depressive disorder (MDD) is derived from studies of chronic stress models in rodents. While these models capture certain aspects of the behavioral and neuroendocrine features of MDD, the extent to which they reproduce the molecular pathology of the human syndrome remains unknown.

METHODS: We systematically compared transcriptional signatures in two brain regions implicated in depression-medial prefrontal cortex and nucleus accumbens-of humans with MDD and of 3 chronic stress models in mice: chronic variable stress, adult social isolation, and chronic social defeat stress. We used differential expression analysis combined with weighted gene coexpression network analysis to create interspecies gene networks and assess the capacity of each stress paradigm to recapitulate the transcriptional organization of gene networks in human MDD.

RESULTS: Our results show significant overlap between transcriptional alterations in medial prefrontal cortex and nucleus accumbens in human MDD and the 3 mouse chronic stress models, with each of the chronic stress paradigms capturing distinct aspects of MDD abnormalities. Chronic variable stress and adult social isolation better reproduce differentially expressed genes, while chronic social defeat stress and adult social isolation better reproduce gene networks characteristic of human MDD. We also identified several gene networks and their constituent genes that are most significantly associated with human MDD and mouse stress models.

CONCLUSIONS: This study demonstrates the ability of 3 chronic stress models in mice to recapitulate distinct aspects of the broad molecular pathology of human MDD, with no one mouse model apparently better than another.

Alternate JournalBiol Psychiatry
PubMed ID32169281
PubMed Central IDPMC7740570
Grant ListP50 MH066172 / MH / NIMH NIH HHS / United States
P50 MH096890 / MH / NIMH NIH HHS / United States
R01 MH051399 / MH / NIMH NIH HHS / United States