Search form

TitleSpatial memory formation requires netrin-1 expression by neurons in the adult mammalian brain.
Publication TypeJournal Article
Year of Publication2019
AuthorsWong, Edwin W., Stephen D. Glasgow, Lianne J. Trigiani, Daryan Chitsaz, Vladimir Rymar, Abbas Sadikot, Edward S. Ruthazer, Edith Hamel, and Timothy E. Kennedy
JournalLearn Mem
Date Published2019 Mar

Netrin-1 was initially characterized as an axon guidance molecule that is essential for normal embryonic neural development; however, many types of neurons continue to express netrin-1 in the postnatal and adult mammalian brain. Netrin-1 and the netrin receptor DCC are both enriched at synapses. In the adult hippocampus, activity-dependent secretion of netrin-1 by neurons potentiates glutamatergic synapse function, and is critical for long-term potentiation, an experimental cellular model of learning and memory. Here, we assessed the impact of neuronal expression of netrin-1 in the adult brain on behavior using tests of learning and memory. We show that adult mice exhibit impaired spatial memory following conditional deletion of netrin-1 from glutamatergic neurons in the hippocampus and neocortex. Further, we provide evidence that mice with conditional deletion of netrin-1 do not display aberrant anxiety-like phenotypes and show a reduction in self-grooming behavior. These findings reveal a critical role for netrin-1 expressed by neurons in the regulation of spatial memory formation.

Alternate JournalLearn. Mem.
PubMed ID30770464
PubMed Central IDPMC6380201