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TitleSpontaneous cortical activity alternates between motifs defined by regional axonal projections.
Publication TypeJournal Article
Year of Publication2013
AuthorsMohajerani, Majid H., Allen W. Chan, Mostafa Mohsenvand, Jeffrey LeDue, Rui Liu, David A. McVea, Jamie D. Boyd, Yu Tian Wang, Mark Reimers, and Timothy H. Murphy
JournalNat Neurosci
Volume16
Issue10
Pagination1426-35
Date Published2013 Oct
ISSN1546-1726
KeywordsAcoustic Stimulation, Animals, Auditory Cortex, Axons, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Nerve Net, Photic Stimulation, Visual Cortex
Abstract

Using millisecond-timescale voltage-sensitive dye imaging in lightly anesthetized or awake adult mice, we show that a palette of sensory-evoked and hemisphere-wide activity motifs are represented in spontaneous activity. These motifs can reflect multiple modes of sensory processing, including vision, audition and touch. We found similar cortical networks with direct cortical activation using channelrhodopsin-2. Regional analysis of activity spread indicated modality-specific sources, such as primary sensory areas, a common posterior-medial cortical sink where sensory activity was extinguished within the parietal association area and a secondary anterior medial sink within the cingulate and secondary motor cortices for visual stimuli. Correlation analysis between functional circuits and intracortical axonal projections indicated a common framework corresponding to long-range monosynaptic connections between cortical regions. Maps of intracortical monosynaptic structural connections predicted hemisphere-wide patterns of spontaneous and sensory-evoked depolarization. We suggest that an intracortical monosynaptic connectome shapes the ebb and flow of spontaneous cortical activity.

DOI10.1038/nn.3499
Alternate JournalNat. Neurosci.
PubMed ID23974708
PubMed Central IDPMC3928052
Grant List12675-5 / / Canadian Institutes of Health Research / Canada
MOP-12675 / / Canadian Institutes of Health Research / Canada