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TitleStentian structural plasticity in the developing visual system.
Publication TypeJournal Article
Year of Publication2020
AuthorsRahman, Tasnia N., Martin Munz, Elena Kutsarova, Olesia M. Bilash, and Edward S. Ruthazer
JournalProc Natl Acad Sci U S A
Volume117
Issue20
Pagination10636-10638
Date Published2020 05 19
ISSN1091-6490
KeywordsAction Potentials, Animals, Axons, Dendrites, Neurogenesis, Neuronal Plasticity, Retinal Ganglion Cells, Synaptic Potentials, Vision, Ocular, Xenopus
Abstract

In a small fraction of tadpoles, a single retinal ganglion cell (RGC) axon misprojects to the ipsilateral optic tectum. Presenting flashes of light to the ipsilateral eye causes that ipsilateral axon to fire, whereas stimulating the contralateral eye excites all other RGC inputs to the tectum. We performed time-lapse imaging of individual ipsilaterally projecting axons while stimulating either the ipsilateral or contralateral eye. Stimulating either eye alone reduced axon elaboration by increasing branch loss. New branch additions in the ipsi axon were exclusively increased by contralateral eye stimulation, which was enhanced by expressing tetanus neurotoxin (TeNT) in the ipsilateral axon, to prevent Hebbian stabilization. Together, our results reveal the existence of a non-cell-autonomous "Stentian" signal, engaged by activation of neighboring RGCs, that promotes exploratory axon branching in response to noncorrelated firing.

DOI10.1073/pnas.2001107117
Alternate JournalProc Natl Acad Sci U S A
PubMed ID32366647
PubMed Central IDPMC7245132
Grant ListFDN-143238 / / CIHR / Canada