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TitleStress-related synaptic plasticity in the hypothalamus.
Publication TypeJournal Article
Year of Publication2015
AuthorsBains, Jaideep S., Jaclyn I. Wamsteek Cusulin, and Wataru Inoue
JournalNat Rev Neurosci
Volume16
Issue7
Pagination377-88
Date Published2015 Jul
ISSN1471-0048
Abstract

Stress necessitates an immediate engagement of multiple neural and endocrine systems. However, exposure to a single stressor causes adaptive changes that modify responses to subsequent stressors. Recent studies examining synapses onto neuroendocrine cells in the paraventricular nucleus of the hypothalamus demonstrate that stressful experiences leave indelible marks that alter the ability of these synapses to undergo plasticity. These adaptations include a unique form of metaplasticity at glutamatergic synapses, bidirectional changes in endocannabinoid signalling and bidirectional changes in strength at GABAergic synapses that rely on distinct temporal windows following stress. This rich repertoire of plasticity is likely to represent an important building block for dynamic, experience-dependent modulation of neuroendocrine stress adaptation.

DOI10.1038/nrn3881
Alternate JournalNat. Rev. Neurosci.
PubMed ID26087679
Grant List / / Canadian Institutes of Health Research / Canada