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TitleTreating Parkinson's Disease with Antibodies: Previous Studies and Future Directions.
Publication TypeJournal Article
Year of Publication2020
AuthorsCastonguay, Anne-Marie, Claude Gravel, and Martin Lévesque
JournalJ Parkinsons Dis
Date Published2020 Oct 22
ISSN1877-718X
Abstract

Parkinson's disease is a neurodegenerative disorder mainly characterized by the degeneration of dopaminergic neurons in the substantia nigra. Degenerating neurons contain abnormal aggregates called Lewy bodies, that are predominantly composed of the misfolded and/or mutated alpha-synuclein protein. Post-translational modifications, cellular stress, inflammation and gene mutations are thought to trigger its pathological misfolding and aggregation. With alpha-synuclein pathology being strongly associated with dopaminergic neuronal toxicity, strategies aimed to reduce its burden are expected to be beneficial in slowing disease progression. Moreover, multiple sources of evidence suggest a cell-to-cell transmission of pathological alpha-synuclein in a prion-like manner. Therefore, antibodies targeting extra- or intracellular alpha-synuclein could be efficient in limiting the aggregation and transmission. Several active and passive immunization strategies have been explored to target alpha-synuclein. Here, we summarize immunotherapeutic approaches that were tested in pre-clinical or clinical studies in the last two decades in an attempt to treat Parkinson's disease.

DOI10.3233/JPD-202221
Alternate JournalJ Parkinsons Dis
PubMed ID33104039