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TitleWide-field quantitative micro-elastography of human breast tissue.
Publication TypeJournal Article
Year of Publication2018
AuthorsAllen, Wes M., Kelsey M. Kennedy, Qi Fang, Lixin Chin, Andrea Curatolo, Lucinda Watts, Renate Zilkens, Synn Lynn Chin, Benjamin F. Dessauvagie, Bruce Latham, Christobel M. Saunders, and Brendan F. Kennedy
JournalBiomed Opt Express
Volume9
Issue3
Pagination1082-1096
Date Published2018 Mar 01
ISSN2156-7085
Abstract

Currently, 20-30% of patients undergoing breast-conserving surgery require a second surgery due to insufficient surgical margins in the initial procedure. We have developed a wide-field quantitative micro-elastography system for the assessment of tumor margins. In this technique, we map tissue elasticity over a field-of-view of ~46 × 46 mm. We performed wide-field quantitative micro-elastography on thirteen specimens of freshly excised tissue acquired from patients undergoing a mastectomy. We present wide-field optical coherence tomography (OCT) images, qualitative (strain) micro-elastograms and quantitative (elasticity) micro-elastograms, acquired in 10 minutes. We demonstrate that wide-field quantitative micro-elastography can extend the range of tumors visible using OCT-based elastography by providing contrast not present in either OCT or qualitative micro-elastography and, in addition, can reduce imaging artifacts caused by a lack of contact between tissue and the imaging window. Also, we describe how the combined evaluation of OCT, qualitative micro-elastograms and quantitative micro-elastograms can improve the visualization of tumor.

DOI10.1364/BOE.9.001082
Alternate JournalBiomed Opt Express
PubMed ID29541505
PubMed Central IDPMC5846515